HCN channelopathy and cardiac electrophysiologic dysfunction in genetic and acquired rat epilepsy models
نویسندگان
چکیده
منابع مشابه
Dendritic ion channelopathy in acquired epilepsy.
Ion channel dysfunction or "channelopathy" is a proven cause of epilepsy in the relatively uncommon genetic epilepsies with Mendelian inheritance. But numerous examples of acquired channelopathy in experimental animal models of epilepsy following brain injury have also been demonstrated. Our understanding of channelopathy has grown due to advances in electrophysiology techniques that have allow...
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http://www.sciencemag.org/cgi/content/full/305/5683/532 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/305/5683/532/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://w...
متن کاملAcquired dendritic channelopathy in temporal lobe epilepsy.
Inherited channelopathies are at the origin of many neurological disorders. Here we report a form of channelopathy that is acquired in experimental temporal lobe epilepsy (TLE), the most common form of epilepsy in adults. The excitability of CA1 pyramidal neuron dendrites was increased in TLE because of decreased availability of A-type potassium ion channels due to transcriptional (loss of chan...
متن کاملProgressive dendritic HCN channelopathy during epileptogenesis in the rat pilocarpine model of epilepsy.
Ion channelopathy plays an important role in human epilepsy with a genetic cause and has been hypothesized to occur in epilepsy after acquired insults to the CNS as well. Acquired alterations of ion channel function occur after induction of status epilepticus (SE) in animal models of epilepsy, but it is unclear how they correlate with the onset of spontaneous seizures. We examined the propertie...
متن کاملLong QT syndrome - a genetic cardiac channelopathy.
INTRODUCTION Long QT-syndrome (LQTS) is a genetic cardiac channelopathy characterised by a prolonged QT interval on a surface electrocardiogram (ECG), syncope, T-wave abnormalities, ventricular tachycardia of the torsades de pointes (TdPVT) type (Fig. 1) and an increased risk of sudden death [1]. LQTS has variable clinical presentation and is genetically characterised by incomplete penetrance, ...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2014
ISSN: 0013-9580
DOI: 10.1111/epi.12563